Light-Directed System Accelerates Evolution of Complex Protein Functions
Scientists have developed a novel protein evolution approach dubbed optovolution that uses light to guide the evolution of proteins with dynamic, multi-state, and computational functions based on specific rules. Details of the work are published in a new Cell paper titled “undefined.” The research was led by scientists at the Swiss Federal Technology Institute of Lausanne (EPFL).
Over the years, scientists have developed various methods for directed evolution of proteins like enzymes and antibodies that are used in household detergents, medicine, and other industries. The challenge with these existing methods is that they are always strongly active which is inconsistent with how biology naturally works. Signaling proteins, protein “switches,” and protein “logic gates”—proteins that combine multiple inputs to make yes or no decisions—change states over time depending on the need. Thus, if a directed evolution approach only selects for one state, the other important states of a protein can lose function or fail to switch properly, which can be biologically detrimental.
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Over the years, scientists have developed various methods for directed evolution of proteins like enzymes and antibodies that are used in household detergents, medicine, and other industries. The challenge with these existing methods is that they are always strongly active which is inconsistent with how biology naturally works. Signaling proteins, protein “switches,” and protein “logic gates”—proteins that combine multiple inputs to make yes or no decisions—change states over time depending on the need. Thus, if a directed evolution approach only selects for one state, the other important states of a protein can lose function or fail to switch properly, which can be biologically detrimental.
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